Endocrine Abstracts

Stiff person syndrome (SPS) is a rare disease characterized by progressive muscle rigidity and spasms, which can lead to functional disability. This condition can be challenging to diagnose if there is no high index of suspicion. Its etiology is unknown, but one of the most likely causes is autoimmune aggression, which is corroborated by that fact that it is associated with other autoimmune diseases in half of the cases described in literature.We will pr...

Multiple benign symmetric lipomatosis (Madelung’s disease, Launois–Bensaude syndrome) is significantly rare disease characterised by symmetrical focal deposition of adipose tissue in the neck, upper part of the arms, back, pelvis, and thigh. Although its etiology is uncertain, it has been associated with genetic factors, mitochondrial inheritance and alcoholism. Its pathogenesis seems to include a dysfunction of cAMP and levels of catecholamines in adipocytes. This c...

Neuroendocrine neoplasia (NENs) are rare tumours that show features of neuroendocrine differentiation. Generally, NENs can be subdivides into high-grade neuroendocrine carcinomas (NECs) and low-to-intermediate grade neuroendocrine tumours (NETs). The most common Endodermal NETs’ localisations are the lungs, ileum, appendix, and rectum. Neuroectodermal NETs include medullary thyroid cancer (MTC), pheochromocytoma (PHEO), and paraganglioma (PGL). Nets are estimated to occur...